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The concomitant administration of esmolol and digoxin resulted in a 10-20 increase in serum digoxin concentrations.

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Trihexyphenidyl moderate anticholinergics, because of their ability to cause tachycardia, can antagonize the beneficial actions of digoxin in atrial fibrillation flutter.

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Digoxin has a narrow therapeutic index, increased monitoring of serum digoxin concentrations and for potential signs and symptoms of clinical toxicity is necessary when initiating, adjusting, or discontinuing drugs that may interact with digoxin.

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